反应详情

A suspension of 5.7 g (16.5 mmol) of the above pyrimidine acid, 20 ml of dimethylformamide, and 5.7 g (35.1 mmol) of carbonyldiimidazole is stirred at 50°-60° C. for 30 minutes and 3 hrs at room temperature. Acetonitrile (40 ml) and ether (40 ml) are added and the product filtered, washed with acetonitrile, ether, and dried to give 6.3 g of the title imidazolide.

1. filtrationthe product filtered
2. washwashed with acetonitrile, ether
3. customdried