Hydrochloric Acid → N-(3,4-dichlorophenyl)-6-(methyloxy)-7-({[2-[(4-methylpiperazin-1-yl)methyl]-1,3-thiazol-4-yl]methyl}oxy)quinazolin-4-amine
Reaction equation
[C:39](=[O:40])([O-:41])[O-:42].[Cl:17][c:18]1[cH:19][c:20]([NH:25][c:26]2[n:27][cH:28][n:29][c:30]3[cH:31][c:32]([OH:38])[c:33]([O:36][CH3:37])[cH:34][c:35]23)[cH:21][cH:22][c:23]1[Cl:24].[Cl:2][CH2:3][c:4]1[n:5][c:6]([CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]2)[s:7][cH:8]1.[ClH:1].[K+:43].[K+:44].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49]>>[CH2:3]([c:4]1[n:5][c:6]([CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]2)[s:7][cH:8]1)[O:38][c:32]1[cH:31][c:30]2[n:29][cH:28][n:27][c:26]([NH:25][c:20]3[cH:19][c:18]([Cl:17])[c:23]([Cl:24])[cH:22][cH:21]3)[c:35]2[cH:34][c:33]1[O:36][CH3:37]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-8755e1fdc6d74fc2b0e6d2a1cb939201
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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