Sodium Hydroxide → HCID 18788822, compound

HRID 1106501Notes

Reaction equation

HRID 1106501 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]([C:18]([F:21])([F:20])[F:19])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].OS([O-])(=O)=O.[Na+]>CO>[CH3:1][C:2]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]([C:18]([F:19])([F:20])[F:21])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 516919Sodium BisulfateHCID 18788775HCID 18788775, compound

Product 1

HCID 18788822HCID 18788822, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.6 g of methyl 2-methyl-4-phenyl-5-trifluoromethylbenzoate were dissolved in 100 ml of MeOH, 20 ml of a 1 N aqueous NaOH solution were added and the solution was stirred at RT for 8 h. The reaction mixture was poured onto 100 ml of a saturated aqueous NaHSO4 solution and extracted 3 times using 100 ml of EA each time. The organic phase was dried over Na2SO4 and the solvent was removed in vacuo.

Workup

  1. extractionextracted 3 times
  2. dry with materialThe organic phase was dried over Na2SO4
  3. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-2a46365cb3054c0f86e6c0b42d357e2e
Source dataset
uspto-grants-2000_05
Patent number
US06057322

Reaction notes

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