Hydrochloric Acid → HCID 70186531, compound

HRID 1106515Notes

Reaction equation

HRID 1106515 reaction equation
[OH:1][CH2:2][C@@H:3]([NH:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:25]>C(O)C>[ClH:25].[OH:1][CH2:2][C@@H:3]([NH:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9927305HCID 9927305, compound

Product 1

HCID 70186531HCID 70186531, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (S)-4-[α-(hydroxymethyl)benzylamino]-6,7dimethoxyquinazoline (325 mg, 1 mmol) in ethanol (2 ml) was added 1N hydrochloric acid (2 ml, 2 mmol) and the resulting mixture was evaporated under vacuum to dryness to give pure title compound in about 100% yield.

Workup

  1. customthe resulting mixture was evaporated under vacuum to dryness

Sources & evidence

ORD record
ord-495a125c252d404ca409fa930b041a87
Source dataset
uspto-grants-2000_05
Patent number
US06057326

Reaction notes

Loading…