反应详情

To 1.18 g of 3-{[2-(benzyloxy)-1-(tetrahydro-2-oxo-3-furyl)ethylidene]amino}pyrazole were added 600 μl of triethylamine and 2.0 ml of water, and the mixture was stirred for 40 minutes while heating under reflux. After the reaction system was allowed to coom to room temperature, 1N hydrochloric acid was added to adjust the pH of the reaction mixture to 4. After the reaction mixture was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off to obtain 1.18 g (yield: quantitative) of the intended product.

1. temperaturewhile heating
2. temperatureunder reflux
3. customto coom to room temperature
4. extractionAfter the reaction mixture was extracted with chloroform
5. dry with materialthe organic layer was dried over anhydrous sodium sulfate
6. distillationthe solvent was distilled off