Hydrochloric Acid → HCID 178516281, compound

HRID 1106536Notes

Reaction equation

HRID 1106536 reaction equation
[CH2:1]([O:8][CH2:9][C:10](=[N:17][C:18]1[CH:22]=[CH:21][NH:20][N:19]=1)[CH:11]1[CH2:15][CH2:14][O:13][C:12]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl>O>[CH2:1]([O:8][CH2:9][C:10]1[NH:17][C:18]2[N:19]([N:20]=[CH:21][CH:22]=2)[C:12](=[O:16])[C:11]=1[CH2:15][CH2:14][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 178519082HCID 178519082, compound

Product 1

HCID 178516281HCID 178516281, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1.18 g of 3-{[2-(benzyloxy)-1-(tetrahydro-2-oxo-3-furyl)ethylidene]amino}pyrazole were added 600 μl of triethylamine and 2.0 ml of water, and the mixture was stirred for 40 minutes while heating under reflux. After the reaction system was allowed to coom to room temperature, 1N hydrochloric acid was added to adjust the pH of the reaction mixture to 4. After the reaction mixture was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off to obtain 1.18 g (yield: quantitative) of the intended product.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. customto coom to room temperature
  4. extractionAfter the reaction mixture was extracted with chloroform
  5. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-3c11e7657ca04640995091ef7fee58b3
Source dataset
uspto-grants-2000_05
Patent number
US06057330

Reaction notes

Loading…