Tetrahydrofuran → 3-(3,5-Dimethoxy-phenyl)-3-(2-methoxy-phenyl)-acrylonitrile

HRID 110662Notes

Reaction equation

HRID 110662 reaction equation
[CH2:21]([O:22][P:23](=[O:24])([O:25][CH2:26][CH3:27])[CH2:29][C:30]#[N:31])[CH3:28].[CH2:66]1[O:67][CH2:68][CH2:69][CH2:70]1.[CH3:1][O:2][c:3]1[cH:4][c:5]([C:11](=[O:12])[c:13]2[c:14]([O:19][CH3:20])[cH:15][cH:16][cH:17][cH:18]2)[cH:6][c:7]([O:9][CH3:10])[cH:8]1.[CH3:32][Si:33]([N-:34][Si:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Li+:41].[O:42]1[c:43]2[cH:44][cH:45][c:46]([C:47]([c:48]3[cH:49][c:50]([O:51][CH3:52])[cH:53][c:54]([O:55][CH3:56])[cH:57]3)=[CH:58][C:59]#[N:60])[cH:61][c:62]2[O:63][CH2:64][CH2:65]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]([C:11]([c:13]2[c:14]([O:19][CH3:20])[cH:15][cH:16][cH:17][cH:18]2)=[CH:29][C:30]#[N:31])[cH:6][c:7]([O:9][CH3:10])[cH:8]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 75676Diethyl (cyanomethyl)phosphonateHCID 3280088Npc316347HCID 692032153-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-3-(3,5-dimethoxyphenyl)acrylonitrileHCID 69203870(3,5-Dimethoxyphenyl)-(2-methoxyphenyl)methanone

Product 1

HCID 692033043-(3,5-Dimethoxy-phenyl)-3-(2-methoxy-phenyl)-acrylonitrile

Sources & evidence

ORD record
ord-8027033a50824595afdee17620617b27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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