Hydrogen chloride-ethyl acetate → HCID 86755376, compound

HRID 1106669Notes

Reaction equation

HRID 1106669 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:43])[CH2:10][CH2:11][CH2:12][N:13]([O:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][N:20]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH:14]=[O:15]>C(OCC)(=O)C>[ClH:1].[ClH:1].[CH3:43][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]([O:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][N:20]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH:14]=[O:15]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57006839HCID 57006839, compound

Product 1

HCID 86755376HCID 86755376, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.21 ml) was added to a solution of N-[3-(dimethylamino)propyl]-[2-(1-octadecyl-2-piperidyl)ethoxy]formamide (0.200 g) in ethyl acetate (4 ml) under argon gas atmosphere, while being cooled with ice. After being stirred for 15 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-hexane, thereby yielding the entitled compound (0.199 g) as white crystals.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-hexane

Sources & evidence

ORD record
ord-5fb954140f734466bb9d506f4aa5a16f
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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