Hydrogen chloride-ethyl acetate → HCID 86755377, compound

HRID 1106670Notes

Reaction equation

HRID 1106670 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:48])[CH2:10][CH2:11][CH2:12][N:13]([O:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][N:20]1[C:25](=[O:47])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[CH:14]=[O:15]>C(OCC)(=O)C>[ClH:1].[CH3:48][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]([O:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][N:20]1[C:25](=[O:47])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[CH:14]=[O:15]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57261757HCID 57261757, compound

Product 1

HCID 86755377HCID 86755377, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.58 ml) was added to a solution of N-[3-(dimethylamino)propyl]-[2-(1-docosanoyl-2-piperidyl)ethoxy]formamide (1.04 g) in ethyl acetate (11 ml) at room temperature. After being stirred for 20 minutes, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (1.12 g) as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-a51825f4fd644acdb3927492f7734565
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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