HCID 15897853, compound → HCID 15897852, compound

HRID 1106671Notes

Reaction equation

HRID 1106671 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:47])[CH2:10][CH2:11][NH:12][C:13](=[O:46])[O:14][CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][N:18]1[C:23](=[O:45])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44]>C(OCC)(=O)C>[ClH:1].[CH3:47][N:9]([CH3:8])[CH2:10][CH2:11][NH:12][C:13](=[O:46])[O:14][CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][N:18]1[C:23](=[O:45])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44]

Participants

4

Reactant 2

HCID 15897853HCID 15897853, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 15897852HCID 15897852, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.34 ml) was added to a solution of 2-(1-docosanoyl-2-piperidyl)ethyl N-[2-(dimethylamino)ethyl]carbamate (2.500 g) in ethyl acetate (25 ml) and the mixture was stirred for 0.5 hour. After the reaction mixture was concentrated, the residue was recrystallized with a mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (2.287 g) as white solid.

Workup

  1. concentrationAfter the reaction mixture was concentrated
  2. customthe residue was recrystallized with a mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-ef5a767f7c104f1da514c3240116929c
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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