HCID 15897855, compound → HCID 15897856, compound

HRID 1106675Notes

Reaction equation

HRID 1106675 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][CH2:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][N:21]2[C:26](=[O:48])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])=[O:16])[CH2:11][CH2:10]1>C(OCC)(=O)C>[ClH:1].[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][CH2:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][N:21]2[C:26](=[O:48])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 15897855HCID 15897855, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 15897856HCID 15897856, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.46 ml) was added to a solution of 2-(1-docosanoyl-2-piperidyl)ethyl 4-methyltetrahydro-1(2H)-pyrazinecarboxylate (2.800 g) in ethyl acetate (28 ml), while being cooled with ice. The mixture was stirred for 30 minutes. After the reaction mixture was concentrated, the residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (2.590 g) as white solid.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationAfter the reaction mixture was concentrated
  3. customthe residue was recrystallized with ethyl acetate

Sources & evidence

ORD record
ord-b5ebbaa6d58a4ed182519973f1187eff
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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