2-Piperidin-2-ylethanol → HCID 86755378, compound

HRID 1106682Notes

Reaction equation

HRID 1106682 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][NH:5]1.C1C=CC2N(O)N=NC=2C=1.[Cl:20][CH2:21][CH2:22][CH2:23][C:24]([O-])=[O:25]>CN(C)C=O>[Cl:20][CH2:21][CH2:22][CH2:23][C:24]([CH:8]1[CH2:7][CH2:6][NH:5][CH:4]([CH2:3][CH2:2][OH:1])[CH2:9]1)=[O:25]

Participants

5

Reactant 3

HCID 151442-Piperidin-2-ylethanolHCID 757711-HydroxybenzotriazoleHCID 22173960HCID 22173960, compound

Product 1

HCID 86755378HCID 86755378, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(2-Hydroxyethyl)piperidine, HOBt and WSCI are added to N,N-dimethylformamide solution of 4-chlorobutyrate while being cooled with ice and the mixture is reacted at room temperature to obtain 1-(4-(chlorobutanoyl)-2-(2-hydroxyethyl)piperidine.

Workup

  1. temperaturewhile being cooled with ice
  2. customthe mixture is reacted at room temperature

Sources & evidence

ORD record
ord-310f3313a8a242d199b178c88655ac08
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

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