反应详情

温度

70 °C

3,5-Dinitrophenol (15.0 g) and 10.75 g of bromoacetonitrile were dissolved in 85 ml of 2-butanone and the solution was treated with 33.78 g of potassium carbonate. The heterogenous mixture was stirred and heated at 70° C. for 5 hours, cooled to room temperature, poured into ethyl acetate, washed with water, dried over magnesium sulfate, and evaporated. The residue was purified by silica gel chromatography eluting with dichloromethane/hexane (3:1) to give 11.24 g of (3,5-dinitrophenoxy)-acetonitrile as a light yellow solid.

1. temperaturecooled to room temperature
2. washwashed with water
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe residue was purified by silica gel chromatography
6. washeluting with dichloromethane/hexane (3:1)