Tert-Butyl nitrite → 2,5-Dimethyl-1,3-dinitrobenzene

Temperature

65 °C

To a solution of t-butyl nitrite (t-BuONO) (7.32 g) in dimethyl formamide (DMF) (50 mL, from Mallinckrodt) at 65° C. was added dropwise a solution of 3,6-dimethyl-2,4-dinitro-phenylamine (10 g, from above) in DMF (50 mL) during 5-10 min. The mixture was heated at 65° C. for 15 min and the solvent was removed under reduced pressure. The residue was partitioned between dichloromethane (300 mL) and half-saturated sodium chloride solution. The dichloromethane solution was washed with additional half-saturated sodium chloride solution (300 mL) and dried over magnesium sulfate. After evaporation of the solvent, the residue was taken up in dichloromethane (250 mL) and passed through a short column (silica gel). Eluting with dichloromethane gave 2,5-dimethyl-1,3-dinitro-benzene (7.75 g).

1. customthe solvent was removed under reduced pressure
2. customThe residue was partitioned between dichloromethane (300 mL) and half-saturated sodium chloride solution
3. washThe dichloromethane solution was washed with additional half-saturated sodium chloride solution (300 mL)
4. dry with materialdried over magnesium sulfate
5. customAfter evaporation of the solvent
6. washEluting with dichloromethane

ORD record

ord-3f54ed6fef5f4406ac5ab2bd3ba7a865

Source dataset

uspto-grants-2000_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06057349