Tetrahydrofuran → 2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclopropyl-ethanol

HRID 110688Notes

Reaction equation

HRID 110688 reaction equation
[Al+3:27].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([C:14](=[O:15])[OH:16])[CH:17]2[CH2:18][CH2:19]2)[cH:20][c:21]([F:25])[c:22]([F:24])[cH:23]3)[cH:6][cH:7]1.[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][OH:15])[CH:17]2[CH2:18][CH2:19]2)[cH:20][c:21]([F:25])[c:22]([F:24])[cH:23]3)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 66619353[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclopropyl-acetic acid

Product 1

HCID 666194522-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclopropyl-ethanol

Sources & evidence

ORD record
ord-48a6495d9526443eb8a5662d9ed6a56e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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