HCID 54451565, compound → HCID 54152782, compound

HRID 1106901Notes

Reaction equation

HRID 1106901 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C@H:15]([N:22]([CH3:36])[C:23](=[O:35])[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[OH:8][C:9]1[CH:10]=[C:11]([C@H:15]([N:22]([CH3:36])[C:23](=[O:35])[CH2:24][C:25]2[CH:26]=[CH:27][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:29][CH:30]=2)[CH2:16][N:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 54451565HCID 54451565, compound

Product 1

HCID 54152782HCID 54152782, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

To a solution of Example 20 (1.79 g, 3.5 mmol) in ethanol (85 mL) was added palladium hydroxide (20% on carbon) (0.15 g). This was hydrogenated at 30° C. for 6 hours, filtered through Celite, and the solvent removed in vacuo to give a white foam, 3.4 mmol, 96%.

Workup

  1. filtrationfiltered through Celite
  2. customthe solvent removed in vacuo
  3. customto give a white foam, 3.4 mmol, 96%

Sources & evidence

ORD record
ord-5884ddf4adf742b78b6b8a44f4c352ea
Source dataset
uspto-grants-2000_05
Patent number
US06057357

Reaction notes

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