Ethanol → HCID 77332212, compound

HRID 1106911Notes

Reaction equation

HRID 1106911 reaction equation
C(OC1C=C([CH:15]([N:30]([CH3:44])[C:31](=[O:43])[CH2:32][C:33]2[CH:38]=[CH:37][C:36]([S:39]([CH3:42])(=[O:41])=[O:40])=[CH:35][CH:34]=2)[CH2:16][CH:17]2[CH2:21][CH2:20][CH:19]([O:22][Si:23]([C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:25])[CH3:24])[CH2:18]2)C=CC=1)C1C=CC=CC=1.[CH2:45]([OH:47])[CH3:46]>[OH-].[Pd+2].[OH-]>[C:26]([Si:23]([CH3:25])([CH3:24])[O:22][CH:19]1[CH2:20][CH2:21][CH:17]([CH:16]([C:18]2[CH:17]=[CH:16][CH:15]=[C:45]([OH:47])[CH:46]=2)[CH2:15][N:30]([CH3:44])[C:31](=[O:43])[CH2:32][C:33]2[CH:34]=[CH:35][C:36]([S:39]([CH3:42])(=[O:40])=[O:41])=[CH:37][CH:38]=2)[CH2:18]1)([CH3:29])([CH3:27])[CH3:28]

Participants

4

Reactant 2

HCID 702EthanolHCID 70298692HCID 70298692, compound

Product 1

HCID 77332212HCID 77332212, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

To a solution of Example 39 (2.41 g, 3.8 mmol) in ethanol (220 mL) was added palladium hydroxide (20% on carbon) (0.15 g). This was hydrogenated at 30° C. for 16 hours, filtered through Celite, and the solvent removed in vacuo to give a white foam, 3.7 mmol, 97%. This was used without further purification.

Workup

  1. filtrationfiltered through Celite
  2. customthe solvent removed in vacuo
  3. customto give a white foam, 3.7 mmol, 97%
  4. customThis was used without further purification

Sources & evidence

ORD record
ord-66436e4c9e714e2096b295b59487a1e6
Source dataset
uspto-grants-2000_05
Patent number
US06057357

Reaction notes

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