Morpholine → MOBS

HRID 1107097Notes

Reaction equation

HRID 1107097 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]1[CH2:14][O:13][S:10](=[O:12])(=[O:11])[CH2:9][CH2:8]1>C(O)(C)C>[N:1]1([CH2:14][CH2:7][CH2:8][CH2:9][S:10]([OH:13])(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 154111,4-Butane sultone

Product 1

HCID 3674064MOBSYield 18%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Morpholine (3.56 g) was dissolved in isopropanol (25 ml) and treated with 1,4-butane sultone (5.58 g) at 10° C. The reaction mixture was allowed to warm to room temperature and stirred for 3 days. The white precipitate that had formed was filtered and dried to give the title compound (1.64 g).

Workup

  1. customThe white precipitate that had formed
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-1e68ecde3bfc4bc1a244b19d6cd88d15
Source dataset
uspto-grants-2000_05
Patent number
US06057457

Reaction notes

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