Trifluoroacetic acid → HCID 18790157, compound

HRID 1107109Notes

Reaction equation

HRID 1107109 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:12][C:13]([OH:15])=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18790170HCID 18790170, compound

Product 1

HCID 18790157HCID 18790157, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of t-butyl 7-phenyl-3-phenylsulfanylheptanoate (1.8 g; 6.5 mmol) in CH2Cl2 (20 mL) is slowly added trifluoroacetic acid (6 mL). The reaction is stirred 5 hours and concentrated in vacuo to yield 7-phenyl-3-phenylsulfanylheptanoic acid which is used directly in Step I.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6aadaadfb1784da3a7eb4ae8dc9f481f
Source dataset
uspto-grants-2000_05
Patent number
US06057369

Reaction notes

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