Citric Acid → HCID 18786757, compound

Temperature

0 °C

A solution of 3-iodo-5-nitrobenzyl alcohol (7.2 g, 25.8 mmol) described in Step B, in CH2Cl2 (325 mL) was cooled to 0° C. and treated with iPr2NEt (6.57 mL, 37.7 mmol) and methane sulfonyl chloride (2.19 mL, 28.2 mmol). After stirring for 1.5 hours at 0° C, the reaction was poured into a separatory funnel containing aqueous 5% citric acid. The layers were separated and the aqueous layer was extracted with CH2Cl2. The organic layers were combined and dried (MgSO4), filtered and concentrated to give an orange oil. This material was dissolved in acetonitrile (325 mL), cooled to 0° C. and treated with tetrabutylammonium fluoride (47 mL, 1 M in THF, 47 mmol) via an addition funnel over about 10 minutes giving a dark blue-green mixture. This was stirred overnight as the reaction warmed to room temperature. TLC analysis (1:1 hexane:ethyl acetate) showed the desired product (Rf =0.56). The reaction was diluted with H2O, concentrated and then extracted with ethyl acetate. The ethyl acetate was dried (MgSO4), filtered and concentrated to give a dark brown oil. This material was dissolved in methanol, treated with 7 g of silica gel, concentrated to a free flowing powder and purified by flash chromatography (hexane then 10:1 hexane:ethyl acetate) to give 3-iodo-5-nitrobenzyl fluoride as a tan solid: mp 50.5-51.5° C.

1. additionthe reaction was poured into a separatory funnel
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with CH2Cl2
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customto give an orange oil
8. temperaturecooled to 0° C.
9. customgiving a dark blue-green mixture
10. stirringThis was stirred overnight as the reaction
11. temperaturewarmed to room temperature

ORD record

ord-e78f2ce64f6f4f3f9760ac6fd6b31168

Source dataset

uspto-grants-2000_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06060038