反应详情

A stirred mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one sulphate (1.0 g), triethylamine (0.42 ml) and diethyl oxalate (1.2 ml) in methoxyethanol (10 ml) was heated under reflux for 7 hours. The reaction mixture was stirred overnight at ambient temperature and a precipitate was collected and washed with water and ethanol to afford a crude product (0.70 g, m.p. 312-315° C.). The crude product together with another sample (0.34 g) similarly prepared was twice recrystallized from dimethylformamide to afford th e title compound, 0.40 g, m.p. 320-321° C.

1. temperaturewas heated
2. temperatureunder reflux for 7 hours
3. customa precipitate was collected
4. washwashed with water and ethanol
5. customto afford a crude product (0.70 g, m.p. 312-315° C.)
6. customwas twice recrystallized from dimethylformamide