Dimethylformamide → α-Phenyl-4-pyridineacetonitrile

HRID 1107432Notes

Reaction equation

HRID 1107432 reaction equation
[CH2:1]([C:8]#[N:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:10][C:11](C)([O-])[CH3:12].[K+].[CH3:16][N:17]([CH:19]=O)C>>[C:2]1([CH:1]([C:11]2[CH:12]=[CH:19][N:17]=[CH:16][CH:10]=2)[C:8]#[N:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 8794PhenylacetonitrileHCID 23665647Potassium tert-butoxide

Product 1

HCID 12870734α-Phenyl-4-pyridineacetonitrile

Procedure

The compound was prepared substantially in accordance with the procedure detailed in Example 12A, using the compound of Example 15A, benzyl cyanide (3.3 ml, 28.7 mmol) and potassium t-butoxide (6.44 g, 57.4 mmol) in 60 ml of DMF.

Workup

  1. customThe compound was prepared substantially in accordance with the procedure

Sources & evidence

ORD record
ord-f03a0112de8e440ebef88f3fd2099a80
Source dataset
uspto-grants-2000_05
Patent number
US06060484

Reaction notes

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