Triphenylphosphine → HCID 9957112, compound

HRID 1107576Notes

Reaction equation

HRID 1107576 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:19])[C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:28]=1.[CH3:29][N:30]1[CH2:35][CH2:34][CH2:33][CH:32](O)[CH2:31]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:19])[C:12]3[CH:13]=[CH:14][C:15]([O:18][CH:32]4[CH2:33][CH2:34][CH2:35][N:30]([CH3:29])[CH2:31]4)=[CH:16][CH:17]=3)=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:28]=1

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 980163-Piperidinol, 1-methyl-HCID 5462977Diethyl azodicarboxylateHCID 98651972-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene

Product 1

HCID 9957112HCID 9957112, compoundYield 21%

Procedure

6-Methoxy-2-(4-methoxyphenyl)-3-(4-hydroxybenzoyl)benzo[b]thiophene (1.17 g, 3.00 mmol), 1-methyl-3-hydroxypiperidine (691 mg, 6.00 mmol), triphenylphosphine (1.57 g, 6.00 mmol), and DEAD (6.0 mmol) were converted to product by the procedure of Example 11 to give 307 mg of the title compound. Yield: 21%. MS(FD) 487(M+). IR (CHCl3) ν max 3010, 2947, 2840, 2795, 1646, 1599, 1476, 1254, 1167.

Sources & evidence

ORD record
ord-938f27edbbee4eb79a9bf93ebe477c6e
Source dataset
uspto-grants-2000_05
Patent number
US06060488

Reaction notes

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