反应详情

温度

120 °C

To ethyl-2-chloroacetoacetate(5.6 g) was added formamide(4.6 g). The reaction mixture was stirred at 120° C. for 12 hours, cooled to 0° C. and aqueous potassium carbonate was added thereto. The mixture was extracted with benzene, dried with anhydrous magnesium sulfate, and concentrated in vacuo to obtain the target product(2.1 g).

1. temperaturecooled to 0° C.
2. extractionThe mixture was extracted with benzene
3. dry with materialdried with anhydrous magnesium sulfate
4. concentrationconcentrated in vacuo