Potassium Carbonate → 2-(2-Benzyloxyethyl)thio-2',4'-difluoroacetophenone

HRID 1108041Notes

Reaction equation

HRID 1108041 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].[CH2:13]([O:20][CH2:21][CH2:22][SH:23])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:13]([O:20][CH2:21][CH2:22][S:23][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5880832-Chloro-1-(2,4-difluorophenyl)ethanoneHCID 14571805Ethanethiol, 2-(phenylmethoxy)-

Product 1

HCID 187866432-(2-Benzyloxyethyl)thio-2',4'-difluoroacetophenoneYield 80.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using 2-chloro-2',4'-difluoroacetophenone (4.5 g, 0.024 mol), 2-benzyloxyethanethiol (4.2 g, 0.025 mol), potassium carbonate (4.0 g, 0.029 mol) and methanol (50 ml), 2-(2-benzyloxyethyl)thio-2',4'-difluoroacetophenone (6.2 g, yield: 80.8%) was obtained as a colorless oil by similar procedures to Example 1.

Sources & evidence

ORD record
ord-0580ba2608454e1892fce587626d7b2d
Source dataset
uspto-grants-2000_05
Patent number
US06063945

Reaction notes

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