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HRID1108044

反应详情

EQUATION

反应方程式

HRID 1108044 的结构方程式

REACTANTS

反应物

3
结构：c1nc[nH]n1
HCID9257

1H-1,2,4-Triazole

C2H3N3

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COCCSC(F)(F)C1(c2ccc(F)cc2F)CO1
HCID15434383

未命名化合物

PRODUCTS

生成物

1
结构：COCCSC(F)(F)C(O)(Cn1cncn1)c1ccc(F)cc1F
HCID15433416

未命名化合物

收率 12.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Using 2-(2,4-difluorophenyl)-1,1-difluoro-1-(2-methoxyethyl)thio-2,3-epoxypropane (13.0 g, 0.044 mol), DMSO (100 ml), 1,2,4-triazole (7.6 g, 0.11 mol) and potassium carbonate (15.2 g, 0.11 mol), 2-(2,4-difluorophenyl)-1,1-difluoro-1-(2-methoxyethyl)thio-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (2.0 g, yield: 12.0%) was obtained as colorless crystals by similar procedures to Example 14.