Hydrochloric Acid → Methyl alpha-(benzoylamino)-4'-sulfo[1,1'-biphenyl]-4-acetate

HRID 1108152Notes

Reaction equation

HRID 1108152 reaction equation
[C:1]([NH:9][CH:10]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([S:26]([OH:29])(=[O:28])=[O:27])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)[C:11]([OH:13])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:31]O>>[C:1]([NH:9][CH:10]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]([S:26]([OH:29])(=[O:28])=[O:27])=[CH:24][CH:25]=2)=[CH:16][CH:15]=1)[C:11]([O:13][CH3:31])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18786431alpha-(Benzoylamino)-4'-sulfo[1,1'-biphenyl]-4-acetic acid

Product 1

HCID 18786424Methyl alpha-(benzoylamino)-4'-sulfo[1,1'-biphenyl]-4-acetate

Procedure

To a mixture of 12.46 g (30.31 mmol) of α-(benzoylamino)-4'-sulfo[1,1'-biphenyl]-4-acetic acid in 60 mL of methanol was added 6 g of anhydrous hydrogen chloride. When the addition was complete, the mixture was stirred for 2.5 h. The solvent was removed under reduced pressure.

Workup

  1. additionWhen the addition
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-7b512b7fd6d94082978c5bcb70248df7
Source dataset
uspto-grants-2000_05
Patent number
US06063932

Reaction notes

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