HCID 12050167, compound → HCID 12050168, compound

HRID 1108242Notes

Reaction equation

HRID 1108242 reaction equation
[CH:1]1([CH2:4][N:5]2[C:13]3[N:12]=[C:11]([CH:14]([CH3:16])[CH3:15])[NH:10][C:9]=3[C:8](=S)[NH:7][C:6]2=[O:18])[CH2:3][CH2:2]1>C(N)CC>[CH:1]1([CH2:4][N:5]2[C:13]3[N:12]=[C:11]([CH:14]([CH3:16])[CH3:15])[NH:10][C:9]=3[C:8]([NH:5][CH2:4][CH2:1][CH3:2])=[N:7][C:6]2=[O:18])[CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 12050167HCID 12050167, compound

Product 1

HCID 12050168HCID 12050168, compound

Reagents, catalysts & solvents 1

HCID 7852PropylamineSolvent

Procedure

5.29 g of 3-cyclopropylmethyl-8-isopropyl-6-thioxanthine and 50 ml of propylamine were heated in a 450 ml reactor to 150° C. After 10 hours, the solution was evaporated to dryness, the residue dissolved in 200 ml of methanol, treated with 0.26 g of charcoal, filtered and concentrated. The crystals were collected, washed and dried to give the title compound (4.81 c) as off-white crystals mp 208-10° C.

Workup

  1. customthe solution was evaporated to dryness
  2. dissolutionthe residue dissolved in 200 ml of methanol
  3. additiontreated with 0.26 g of charcoal
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe crystals were collected
  7. washwashed
  8. customdried

Sources & evidence

ORD record
ord-78473e04a44944a9bbe93caa60b39bc5
Source dataset
uspto-grants-2000_05
Patent number
US06066641

Reaction notes

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