Lithium hydroxide, monohydrate → HCID 70298542, compound

HRID 1108505Notes

Reaction equation

HRID 1108505 reaction equation
[C:1]([C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][C:15]([O:17]C)=[O:16])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].O.[OH-].[Li+].[ClH:24].CCOCC>C1COCC1.O>[ClH:24].[C:1]([C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2]

Participants

6

Reactant 3

HCID 168937Lithium hydroxide, monohydrateHCID 10953452Ether hydrochlorideHCID 18785133HCID 18785133, compound

Product 1

HCID 70298542HCID 70298542, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of the methyl ester 5 (1.10 g) in 10 mL of THF and 5 mL of water was added lithium hydroxide monohydrate (172 mg). After two hours, the reaction was cooled to 0° C., and a 1 M solution of HCl/ether (8.2 mL) was added. The solution was concentrated and dried in vacuo next to P2O5 to provide the product 6 as a white solid.

Workup

  1. concentrationThe solution was concentrated
  2. dry with materialdried in vacuo next to P2O5

Sources & evidence

ORD record
ord-65859fde2b2b44b684fd3a52422205bc
Source dataset
uspto-grants-2000_05
Patent number
US06066738

Reaction notes

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