反应详情

温度

100 °C

Subsequently, 1-(2-chloroethyl)indole (15.4 g), potassium methacrylate (21.3 g), potassium iodide (7.1 g), N,N-dimethylformamide (40 ml), and a small amount of hydroquinone were placed in a 200-ml flask equipped with a stirrer and a condenser tube. The mixture was heated to 100° C. and stirred for 2.5 hours. After completion of reaction, insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure. This reaction mixture was purified further by silica gel column chromatography to obtain 1-(2-methacryloyloxyethyl) indole (15.5 g).

1. customequipped with a stirrer and a condenser tube
2. customAfter completion of reaction, insoluble matter
3. customwas removed by filtration
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThis reaction mixture was purified further by silica gel column chromatography