Trifluoroacetic acid → Trifluoroacetate

HRID 1108567Notes

Reaction equation

HRID 1108567 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]1)=O)(C)(C)C.[F:16][C:17]([F:22])([F:21])[C:18]([OH:20])=[O:19]>>[CH3:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1=[O:15].[F:16][C:17]([F:22])([F:21])[C:18]([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18783916Tert-butyl 4-methyl-3-oxopiperazine-1-carboxylate

Product 2

HCID 84468TrifluoroacetateHCID 43990421-Methylpiperazin-2-one

Procedure

1-tert-Butoxycabonyl-4-methyl-3-oxopiperazine (3.87 g) was dissolved in trifluoroacetic acid (80 ml), and the mixture stirred at ambient temperature for 2 hours. Solvent was evaporated to give 1-methyl-2-oxopiperazine as a trifluoroacetate salt, with some excess trifluoroacetic acid.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-43b1a1cfe2f448ff8d6ddd42b1258618
Source dataset
uspto-grants-2000_05
Patent number
US06069145

Reaction notes

Loading…