Hydrochloric Acid → HCID 22627477, compound

HRID 1108730Notes

Reaction equation

HRID 1108730 reaction equation
[C:1]([C:6]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([NH2:17])=[O:16])=[CH:12][CH:13]=2)[N:8]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:7]=1[CH2:25][CH2:26][CH3:27])(=[O:5])[CH:2]([CH3:4])[CH3:3].[ClH:28]>C(Cl)(Cl)Cl.CO>[ClH:28].[C:1]([C:6]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([NH2:17])=[O:16])=[CH:12][CH:13]=2)[N:8]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:7]=1[CH2:25][CH2:26][CH3:27])(=[O:5])[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22627245HCID 22627245, compound

Product 1

HCID 22627477HCID 22627477, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent

Procedure

To a solution of 3-isobutyryl-2-propyl-1-(2-pyridylmethyl)indole-6-carboxamide (80 mg) in chloroform (2 ml) was added 1M solution of hydrogen chloride in methanol (1 ml) at 25° C., and the mixture was stirred for 15 minutes. After evaporation of solvent, the residue was crystallized from a mixture of ethanol and ethyl acetate to give 3-isobutyryl-2-propyl-1-(2-pyridylmethyl)indole-6-carboxamide hydrochloride (80 mg) as colorless crystals.

Workup

  1. customAfter evaporation of solvent
  2. customthe residue was crystallized from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-37d1f843b886436c92a1215e46053fb7
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

Loading…