Hydrochloric Acid → HCID 22627457, compound

HRID 1108736Notes

Reaction equation

HRID 1108736 reaction equation
C(OC([NH:8][C:9]1[CH:17]=[C:16]2[C:12]([C:13]([C:29](=[O:33])[CH:30]([CH3:32])[CH3:31])=[C:14]([CH2:26][CH2:27][CH3:28])[N:15]2[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])=[CH:11][CH:10]=1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[ClH:25].[NH2:8][C:9]1[CH:17]=[C:16]2[C:12]([C:13]([C:29](=[O:33])[CH:30]([CH3:32])[CH3:31])=[C:14]([CH2:26][CH2:27][CH3:28])[N:15]2[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22627494HCID 22627494, compound

Product 1

HCID 22627457HCID 22627457, compoundYield 105.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 6-tert-butoxycarbonylamino-1-(2-chlorobenzyl)-3-isobutyryl-2-propylindole (110 mg) in ethyl acetate (1 ml) was added 4N hydrogen chloride in ethyl acetate at 20° C., and the mixture was stirred at the same temperature for 4 hours. The precipitates were collected by filtration and washed with ethyl acetate to give 6-amino-1-(2-chlorobenzyl)-3-isobutyryl-2-propylindole hydrochloride (50 mg) as powder.

Workup

  1. filtrationThe precipitates were collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-dd7f55a9a8cd412c95348c4e6617e780
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

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