反应详情

47% Hydrobromic acid (140 ml) was gradually added to (trans)-3-(3-methoxyphenyl) cyclohexylamine (14.0 g) and the mixture was refluxed for an hour. After adjusting the reaction solution to pH7 with sodium bicarbonate (powder), it was adjusted to pH9 with concentrated ammonia water. After filtering the deposited crystals by suction and washing with water, they were dried by ventilation at 45° C. for 5 hours to give 8.58 g of (trans)-3-(3-aminocyclohexyl)phenol (65.8% yield).

1. temperaturethe mixture was refluxed for an hour
2. filtrationAfter filtering the deposited crystals by suction
3. washwashing with water, they
4. customwere dried by ventilation at 45° C. for 5 hours