HCID 18784135, compound → HCID 18784188, compound

HRID 1108769Notes

Reaction equation

HRID 1108769 reaction equation
[CH2:1]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:23].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:23].[CH2:1]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)[CH2:11]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 18784135HCID 18784135, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18784188HCID 18784188, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-Benzyl-N-[3-(4-methoxyphenyl)cyclopentylmethyl]amine (free compound, 5.60 g) was dissolved in ethyl acetate (100 ml), 4 N HCl-ethyl acetate solution (10 ml) was added, and the mixture was stirred at room temperature for 2 hours. The deposited crystals were filtered and air-dried to give 6.30 g of N-benzyl-N-[3-(4-methoxyphenyl) cyclopentylmethyl]amine hydrochloride (quantitative yield).

Workup

  1. filtrationThe deposited crystals were filtered
  2. customair-dried

Sources & evidence

ORD record
ord-f718532fe9284514b30dc11558683c2e
Source dataset
uspto-grants-2000_05
Patent number
US06069176

Reaction notes

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