Tert-Butyl nitrite → HCID 22120900, compound

HRID 1108837Notes

Reaction equation

HRID 1108837 reaction equation
N[C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21]1[O:25][N:24]=[C:23]([Br:26])[CH:22]=1.N(OC(C)(C)C)=O>O1CCCC1>[Br:26][C:23]1[CH:22]=[C:21]([C:3]2[C:4]([C:19]#[N:20])=[N:5][N:6]([C:7]3[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:15])[F:16])=[CH:9][C:8]=3[Cl:18])[CH:2]=2)[O:25][N:24]=1

Participants

4

Reactant 2

HCID 10906Tert-Butyl nitriteHCID 9934269HCID 9934269, compound

Product 1

HCID 22120900HCID 22120900, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of 5-amino-4-(3-bromoisoxazol-5-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.1 g) in tetrahydrofuran (1.5 ml) was added t-butyl nitrite (77 μl). The mixture was heated to 65° C. for 1 hour, then cooled and evaporated. The residue was taken up in t-butanol and freeze dried to give the title compound as a pale yellow solid, m.p. 145° C.

Workup

  1. temperaturecooled
  2. customevaporated
  3. customfreeze dried

Sources & evidence

ORD record
ord-c876e35afa00452c81074d0eafc0a2f7
Source dataset
uspto-grants-2000_05
Patent number
US06069157

Reaction notes

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