反应详情

温度

65 °C

To a solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(furan-3-yl)pyrazole (0.204 g) in tetrahydrofuran (3 ml) was added t-butyl nitrite (187.8 μl). The mixture was heated to 65° C. for 1 hour, then cooled and evaporated The residue was purified by column chromatography on silica gel (5 g) eluted with hexane containing increasing amounts of dichloromethane (up to 100%). Combination and evaporation of appropriate fraction gave the title compound as a white solid, m.p. 139° C.

1. temperaturecooled
2. customevaporated The residue
3. customwas purified by column chromatography on silica gel (5 g)
4. washeluted with hexane containing
5. temperatureincreasing amounts of dichloromethane (up to 100%)
6. customCombination and evaporation of appropriate fraction