Potassium Carbonate → HCID 178444334, compound

HRID 1108914Notes

Reaction equation

HRID 1108914 reaction equation
[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:19]=[CH:18][C:15]([CH2:16]Br)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[F:20][C:21]([F:30])([F:29])[C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:19]=[CH:18][C:15]([CH2:16][O:28][C:25]3[CH:26]=[CH:27][C:22]([C:21]([F:20])([F:29])[F:30])=[CH:23][CH:24]=3)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 678744-(Trifluoromethyl)phenolHCID 178444299HCID 178444299, compound

Product 1

HCID 178444334HCID 178444334, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 0.03 m of p-(trans-4-pentylcyclohexyl)-benzyl bromide (obtainable from p-(trans-4-pentylcyclohexyl)-benzoic acid), 0.03 m of p-(trifluoromethyl)-phenol, 0.03 m of potassium carbonate and 40 ml of DMF are warmed to 120° while stirring under the exclusion of air and, after cooling, worked up as usual. p-(Trifluoromethyl)-phenyl p-(trans-4-pentylcyclohexyl)benzyl ether is obtained.

Workup

  1. temperatureare warmed to 120°
  2. temperatureafter cooling

Sources & evidence

ORD record
ord-8624cb544585439fab2fb91117fcbb5e
Source dataset
uspto-grants-1994_06
Patent number
US05318721

Reaction notes

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