Water → HCID 178444582, compound

HRID 1108916Notes

Reaction equation

HRID 1108916 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][CH:4]=1.[CH2:13]([CH:18]([CH2:21]O)[CH2:19][OH:20])[CH2:14][CH2:15][CH2:16][CH3:17].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:13]([C@@H:18]1[CH2:19][O:20][C@@H:7]([C:6]2[CH:9]=[CH:10][C:3]([C:2]([F:11])([F:12])[F:1])=[CH:4][CH:5]=2)[O:8][CH2:21]1)[CH2:14][CH2:15][CH2:16][CH3:17]

Participants

6

Reactant 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 679964-(Trifluoromethyl)benzaldehydeHCID 1175092-Pentyl-1,3-propanediol

Product 1

HCID 178444582HCID 178444582, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

An equimolar mixture of p-trifluoromethylbenzaldehyde and 2-pentylpropane-1,3-diol in toluene is boiled on a water separator with catalysis by p-toluenesulfonic acid. When the water separation is complete and after conventional work-up, p-(trans-5-n-pentyl-1,3-dioxan-2-yl)-trifluorotoluene, m.p. 44.3°, Δε=+12.9, is obtained.

Workup

  1. customWhen the water separation

Sources & evidence

ORD record
ord-101fa1da6c0f46b0ae3d6252e2448807
Source dataset
uspto-grants-1994_06
Patent number
US05318721

Reaction notes

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