Benzyl Bromide → HCID 54352100, compound

HRID 1108954Notes

Reaction equation

HRID 1108954 reaction equation
Cl.[C:2]([NH:5][C@@H:6]1[CH2:10][NH:9][C@@H:8]([CH3:11])[CH2:7]1)(=[O:4])[CH3:3].C(N(CC)CC)C.[CH2:19](Br)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(Cl)Cl>[C:2]([NH:5][C@@H:6]1[CH2:10][N:9]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C@@H:8]([CH3:11])[CH2:7]1)(=[O:4])[CH3:3]

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 8471TriethylamineHCID 67713169HCID 67713169, compound

Product 1

HCID 54352100HCID 54352100, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(2S,4S)-4-acetamido-2-methylpyrrolidine hydrochloride from the previous step is suspended in methylene chloride, triethylamine and benzyl bromide are added and the mixture heated at reflux. The product is obtained after washing and evaporation of the solvent.

Workup

  1. temperaturethe mixture heated
  2. temperatureat reflux
  3. customThe product is obtained
  4. washafter washing
  5. customevaporation of the solvent

Sources & evidence

ORD record
ord-baa17c0b8e6348348efaf0505fc733aa
Source dataset
uspto-grants-1994_06
Patent number
US05318965

Reaction notes

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