Hydrochloric Acid → 1-(2-Amino-2-phenylacetyl)-4-decylpiperazine

HRID 1108961Notes

Reaction equation

HRID 1108961 reaction equation
C(OC([N:8](C1C=CC=CC=1)[CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.Cl.C(O[CH2:39][CH3:40])(=O)C.Cl>C(OCC)(=O)C>[NH2:8][CH:9]([C:40]1[CH:39]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:10]([N:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:16][CH2:17]1)=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21866389Hydrogen chloride-ethyl acetateHCID 54231837HCID 54231837, compound

Product 1

HCID 190216191-(2-Amino-2-phenylacetyl)-4-decylpiperazineYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2.9 g (6.32 mmole) quantity of 1-(N-t-butoxycarbonylphenylglycyl)-4-decylpiperazine was dissolved in 5 ml of ethyl acetate, and 20 ml of 4N hydrochloric acid-ethyl acetate solution was added thereto with ice-cooling and the mixture was stirred for 1 hour. The precipitated crystals were collected by filtration, washed with a small quantity of ether and dried under reduced pressure, giving 2.5 g (yield: 90 %) of 1-(2-amino-2-phenylacetyl)-4-decylpiperazine as a hydrochloride.

Workup

  1. temperaturewith ice-cooling
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with a small quantity of ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-1f2a4ae5431a468ebdfdab1e64540aeb
Source dataset
uspto-grants-1994_06
Patent number
US05318970

Reaction notes

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