1H-1,2,4-Triazole → HCID 86745200, compound

HRID 1108971Notes

Reaction equation

HRID 1108971 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10](CCl)[C:9]1=[O:20])C1C=CC=CC=1.[Na].[NH:22]1[CH:26]=[N:25][CH:24]=[N:23]1.CO.ClCCl>CN(C=O)C>[N:22]1([CH2:1][N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][C:9]2=[O:20])[CH:26]=[N:25][CH:24]=[N:23]1

Participants

6

Reactant 4

HCID 92571H-1,2,4-TriazoleHCID 5360545SodiumHCID 19021627HCID 19021627, compoundHCID 21226129Dichloromethane methanol

Product 1

HCID 86745200HCID 86745200, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

React 1-benzyl-3-chloromethyl-2(1H)-quinolone with the sodium salt of 1,2,4-triazole in DMF at 25° C. for 18 hours, following the procedure of example 22. Chromatograph the crude product using 5% methanol-dichloromethane to obtain the major product, 1-Benzyl-3-(1H-1,2,4-triazol-1-ylmethyl-2(1H)-Quinolone.

Sources & evidence

ORD record
ord-31495cb0dc4240c0b424e2484db708d7
Source dataset
uspto-grants-1994_06
Patent number
US05318971

Reaction notes

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