Dimethylformamide → 1-phenyl-7-chloro-3-(1H-1,2,4-triazol-1-ylmethyl)-2(1H)-quinolone

HRID 1108973Notes

Reaction equation

HRID 1108973 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([CH2:19]Cl)[C:8](=[O:18])[N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.N1C=[CH:24][N:23]=[N:22]1.[Na].[CH3:27][N:28](C=O)C>>[C:12]1([N:9]2[C:10]3[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:11]=3)[CH:6]=[C:7]([CH2:19][N:23]3[CH:24]=[N:28][CH:27]=[N:22]3)[C:8]2=[O:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 190216307-chloro-1-phenyl-3-chloromethyl-2(1H)-quinoloneHCID 178507080HCID 178507080, compound

Product 1

HCID 190216371-phenyl-7-chloro-3-(1H-1,2,4-triazol-1-ylmethyl)-2(1H)-quinolone

Procedure

Following the procedure of example 22, react 7-chloro-1-phenyl-3-chloromethyl-2(1H)-quinolone with sodium triazole in DMF. Chromatograph to obtain the major product, 1-phenyl-7-chloro-3-(1H-1,2,4-triazol-1-ylmethyl)-2(1H)-quinolone.

Sources & evidence

ORD record
ord-7d455a825aa44506a65ff779b87cdd04
Source dataset
uspto-grants-1994_06
Patent number
US05318971

Reaction notes

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