Triethylamine → HCID 54470755, compound

HRID 1109305Notes

Reaction equation

HRID 1109305 reaction equation
[Br-].[CH3:2][N:3]([CH3:14])[NH:4][C:5]([N:7]1[CH2:11][CH2:10][CH:9]([PH3+])[C:8]1=[O:13])=[O:6].[C:15]([C:19]1[CH:20]=[C:21]([CH:24]=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:26]=1[OH:27])[CH:22]=O)([CH3:18])([CH3:17])[CH3:16].C(N(CC)CC)C>>[CH3:2][N:3]([CH3:14])[NH:4][C:5]([N:7]1[CH2:11][CH2:10][C:9](=[CH:22][C:21]2[CH:20]=[C:19]([C:15]([CH3:16])([CH3:18])[CH3:17])[C:26]([OH:27])=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:24]=2)[C:8]1=[O:13])=[O:6]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 732193,5-Di-tert-butyl-4-hydroxybenzaldehydeHCID 19022088HCID 19022088, compound

Product 1

HCID 54470755HCID 54470755, compoundYield 46.4%

Procedure

Substantially in the same manner as in Example 39 (3), 8.31 g of the thus obtained {1-(N-dimethylaminocarbamoyl)-2-oxopyrrolidin-3-yl}phosphonium bromide, 3.79 g (16.2 mmol) of 3,5-di-tert-butyl-4-hydroxybenzaldehyde and 4.51 ml (32.4 mmol) of triethylamine were treated to give 2.91 g of the objective compound (Ia-26) in 46.4% yield.

Sources & evidence

ORD record
ord-0dbc81bbcde74beeae65edcb581e1229
Source dataset
uspto-grants-1994_06
Patent number
US05319100

Reaction notes

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