反应详情

A mixture containing 2-(chloromethyl)quinoline hydrochloride (100.0 g), 4-acetamidophenol (70.69 g) and milled anhydrous potassium carbonate (194 g) was stirred in DMF (1.2 L) using a mechanical stirrer for 48 hours. The mixture was carefully poured onto ice/water (3 L) with vigourous stirring. After the ice had melted, the solid was filtered and rinsed thoroughly with water. It was recrystallized from 95% ethanol and filtered to give the title compound in three crops.

1. customfor 48 hours
2. additionThe mixture was carefully poured onto ice/water (3 L) with vigourous stirring
3. filtrationthe solid was filtered
4. washrinsed thoroughly with water
5. customIt was recrystallized from 95% ethanol
6. filtrationfiltered