4-Aminobenzyl alcohol → HCID 19019485, compound

HRID 1109764Notes

Reaction equation

HRID 1109764 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1Cl)([O-:3])=[O:2].[NH2:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][OH:17])=[CH:14][CH:13]=1.C(=O)(O)[O-].[Na+]>C(O)C>[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][OH:17])=[CH:14][CH:13]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 693314-Aminobenzyl alcoholHCID 516892Sodium BicarbonateHCID 27357814-Chloro-3-nitropyridine

Product 1

HCID 19019485HCID 19019485, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to Preparation Al 88.5 g of 3-nitro-4-chloropyridine, 68.7 g of 4-aminobenzyl alcohol and 46.9 g of sodium bicarbonate in 500 ml of ethanol to give 56.3 g of the titled intermediate.

Sources & evidence

ORD record
ord-ee9f6f3e432e4d1192f289041fc3a600
Source dataset
uspto-grants-1994_06
Patent number
US05322847

Reaction notes

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