Hydrochloric Acid → HCID 131718521, compound

HRID 1110023Notes

Reaction equation

HRID 1110023 reaction equation
[C:1]1([NH2:12])[C:6](F)=[C:5](F)[C:4](F)=[C:3](N)[C:2]=1F.[ClH:13].Cl.Cl.[CH3:16][CH2:17]OCC.[CH:21](O)([CH3:23])[CH3:22]>>[ClH:13].[ClH:13].[CH:16]1[C:2]2=[C:1]3[C:6](=[CH:5][CH:4]=[CH:3]2)[CH2:23][CH2:21][CH2:22][N:12]3[CH:17]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 3776IsopropanolHCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

Product 1

HCID 131718521HCID 131718521, compound

Procedure

To convert the product to the corresponding dihydrochloride, the title base was dissolved in isopropanol. Isopropanolic hydrochloric acid and then ether were added to the solution. The resulting precipitate was filtered out. 250 mg of 2-[4-(4-hydroxybutoxy)phenyl]-1-{2-[4-(4-methylpyridin-2-yl)piperazin-1-yl)piperazin-1-yl)ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 2 HCl 2 H2O having a melting point of 150° C. were obtained.

Workup

  1. filtrationThe resulting precipitate was filtered out

Sources & evidence

ORD record
ord-9bb5d233afa54e6889c65e7531b3e5f3
Source dataset
uspto-grants-1994_06
Patent number
US05324725

Reaction notes

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