Potassium Iodide → HCID 9929493, compound

HRID 1110029Notes

Reaction equation

HRID 1110029 reaction equation
CC1N2C3C(CCC2)=CC=CC=3C=1CCN1CCNCC1.BrC1C=C(C)C=CN=1.[I-].[K+].Cl.Cl.Cl.[CH3:35][C:36]1[N:46]2[C:47]3[C:42]([CH2:43][CH2:44][CH2:45]2)=[CH:41][CH:40]=[CH:39][C:38]=3[C:37]=1[CH2:48][CH2:49][N:50]1[CH2:55][CH2:54][N:53]([C:56]2[CH:61]=[C:60]([CH3:62])[CH:59]=[CH:58][N:57]=2)[CH2:52][CH2:51]1>CN(C)C=O.C(N(CC)CC)C>[CH3:35][C:36]1[N:46]2[C:47]3[C:42]([CH2:43][CH2:44][CH2:45]2)=[CH:41][CH:40]=[CH:39][C:38]=3[C:37]=1[CH2:48][CH2:49][N:50]1[CH2:51][CH2:52][N:53]([C:56]2[CH:61]=[C:60]([CH3:62])[CH:59]=[CH:58][N:57]=2)[CH2:54][CH2:55]1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 27340872-Bromo-4-methylpyridineHCID 19018620HCID 19018620, compoundHCID 19018651HCID 19018651, compound

Product 1

HCID 9929493HCID 9929493, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolvent

Procedure

g of 5,6-dihydro-2-methyl-1-[2-(piperazin-1-yl)-ethyl]-4H-pyrrolo[3,2,1-ij]quinoline, 1.45 g of 2-bromo-4-methylpyridine, 0.175 g of potassium iodide and 3 ml of triethylamine were heated at a temperature of 85° C. for 7 hours in 50 ml of dimethylformamide. The reaction mixture was worked up as described in Example 1H), and the crude title base obtained was converted into 5,6-dihydro-2-methyl-1-(2-[4-(4-methylpyridin-2-yl)piperazin-1-yl]ethyl}-4H-pyrrolo[3,2,1-ij]quinoline trihydrochloride having a melting point of 254° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-5684c560fa484afd9dde4fda03599d22
Source dataset
uspto-grants-1994_06
Patent number
US05324725

Reaction notes

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