Methane → 2-[(4-Piperidyl)carbonyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

HRID 1110765Notes

Reaction equation

HRID 1110765 reaction equation
[CH2:1]1[C:6]2[NH:7][C:8]3[C:13]([C:5]=2[CH2:4][CH2:3][N:2]1[C:14]([CH:16]1[CH2:21][CH2:20][N:19](C(OCC2C=CC=CC=2)=O)[CH2:18][CH2:17]1)=[O:15])=[CH:12][CH:11]=[CH:10][CH:9]=3.CO.C>ClCCl>[NH:19]1[CH2:20][CH2:21][CH:16]([C:14]([N:2]2[CH2:3][CH2:4][C:5]3[C:13]4[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=4)[NH:7][C:6]=3[CH2:1]2)=[O:15])[CH2:17][CH2:18]1

Participants

5

Reactant 3

HCID 297MethaneHCID 887MethanolHCID 14405643HCID 14405643, compound

Product 1

HCID 144056442-[(4-Piperidyl)carbonyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

32 g (76.65 mmol) of benzyl 4-[(1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl)carbonyl]-1-piperidinecarboxylate, 300 ml of methanol, 300 ml of dichloromethane and 9 g of palladinized charcoal (10% palladium) are introduced into a Parr apparatus, and a hydrogenolysis is performed under approximately 0.41 MPa for 18 h.

Sources & evidence

ORD record
ord-28a197ff03804d348d4d2424f15b1d5c
Source dataset
uspto-grants-1990_12
Patent number
US04977159

Reaction notes

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