Pyridine → HCID 86744420, compound

HRID 1111041Notes

Reaction equation

HRID 1111041 reaction equation
[N-:1]=[C:2]=[O:3].[CH2:4]([O:7][C:8](=[O:14])[C@H:9]([CH:11]([CH3:13])[CH3:12])[NH2:10])[CH:5]=[CH2:6].[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl.N[OH:23].C(OC)(OC)OC.[CH2:31]1COC[CH2:32]1>CO>[OH:23][N:15]=[CH:20][C:19]1[CH:32]=[CH:31][C:16]([NH:1][C:2]([NH:10][CH:9]([C:8]([O:7][CH2:4][CH:5]=[CH2:6])=[O:14])[CH:11]([CH3:12])[CH3:13])=[O:3])=[CH:17][CH:18]=1

Participants

7

Reactant 5

HCID 1049PyridineHCID 8028Tetrahydrofuran2×HCID 9005Trimethyl orthoformateHCID 443297Hydroxyamine hydrochlorideHCID 86744419HCID 86744419, compound

Product 1

HCID 86744420HCID 86744420, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.1 mol of p-aminobenzaldehyde ethylene glycol acetal in 100 mL of anhydrous THF is added dropwise over 10 minutes to a solution of 0.1 mol of valine allyl ester isocyanate and 0.35 mol pyridine in 100 mL THF at room temperature under N2. The reaction mixture is stirred at room temperature for 2 hours. After 2 hours the solvent is removed by rotary evaporator. A solution of 0.11 mmol hydroxylamine hydrochloride and 0.1 mol trimethyl orthoformate in CH3OH is added, and the reaction mixture is heated to reflux under N2 for 1 hour. The reaction mixture is reduced to about 1/4 volume by rotary evaporator, and water is added. The product, N-[4-(hydroxyiminomethyl)phenyl]-N'-[1-(allyloxycarbonyl)-2-methylpropyl]urea, is isolated by filtration and dried in vacuo.

Workup

  1. customAfter 2 hours the solvent is removed by rotary evaporator
  2. temperaturethe reaction mixture is heated
  3. temperatureto reflux under N2 for 1 hour
  4. customThe reaction mixture is reduced to about 1/4 volume by rotary evaporator, and water
  5. additionis added

Sources & evidence

ORD record
ord-2bb890f7e8f142ebae150131abf86a6f
Source dataset
uspto-grants-1990_12
Patent number
US04977272

Reaction notes

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