反应详情

A solution of 0.06 mol of N-(allyloxycarbonyl)glycine, prepared as described by F. Guibe, O. Dangles, and G. Balavione in Tetrahedron Letters, 1986, 27, 2365-2368, and 0.066 mol of HCl in 100 mL of CH3OH is stirred at reflux for 8 hours. The solution is then cooled and treated with 0.066 mol of sodium bicarbonate. The solvent is removed by rotary evaporator, and the residue is dissolved in diethyl ether, filtered, dried over MgSO4, and filtered. The solvent is removed by rotary evaporator to give N-(allyloxycarbonyl)glycine methyl ester.

1. temperatureat reflux for 8 hours
2. temperatureThe solution is then cooled
3. customThe solvent is removed by rotary evaporator
4. dissolutionthe residue is dissolved in diethyl ether
5. filtrationfiltered
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customThe solvent is removed by rotary evaporator